Harriers needed to tighten up defensively in the second period before they could even think of taking any points away from the Division Three game.
They were not making any great early impression, although Medou-Otye charged forward from his left-back position to rifle a 25-yard rasper just wide of Barnes's left-hand post on 51 minutes.
Drewe Broughton needed treatment eight mintes into the second half after what appeared to be an off-the-ball clash with Blackpool's towering centre-half Daniel Shittu.
He needed brief treatment for a knock on the head before continuing.
Blackpool midfielder Bushell tested Clarke on 59 minutes with a low effort which flew straight at the Harriers keeper.
Wellens appeared to have put the game beyond Harriers reach on 61 minutes when he latched onto Bushell's through-ball and tucked home a low shot which keeper Clarke could only help into his net.
Murphy completed his hat-trick in the 65th minute when he confidently tucked home a penalty after Hinton had brought down the rampaging Wellens.
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